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KMID : 0380619940260050585
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Korean Journal of Food Science and Technology
1994 Volume.26 No. 5 p.585 ~ p.589
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Effect of T - 2 Toxin on the Mitogen - Induced Blastogenesis in Chick Splenic Cell
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Eo Y.-J.
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Abstract
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The effects of T-2 toxin on mitogen-induced blastogenesis of chick splenic cells were investigated. The [³H] thymidine incorporation in splenic cells stimulated by lipopolysaccharide and concanavalin A were equally inhibited as the concentration of T-2 toxin was increased. The effective dose of T-2 toxin causing a 50% reduction of [³H] thymidine incorporation was inbetween 1.0 and 5.0 ng/ml for both mitogens. Mitogen-induced blastogenesis in chick splenic cells showed differences among experimental groups with different exposure time of T-2 toxin, exhibiting the most inhibition in the experimental group exposed to T-2 toxin at both embryonic and chick periods.
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